Description
GLP-1 SG is a derivative of GLP-1, a naturally occurring peptide hormone that regulates blood sugar levels and insulin secretion. Research indicates that GLP-1 SG can potentially improve heart, liver, and lung function while also slowing or preventing the effects of Alzheimer’s disease. By delaying gastric emptying and reducing intestinal motility, GLP-1 SG effectively decreases appetite. This GLP-1 analog stimulates insulin secretion and suppresses glucagon secretion in a glucose-dependent manner.
GLP-1, a short peptide hormone approximately 30-31 amino acids in length, plays a crucial role in lowering blood sugar levels by enhancing insulin secretion. It has also been associated with neurotrophic effects in the brain and is involved in protecting beta cell insulin stores and promoting nervous system function. In the gastrointestinal system, GLP-1 significantly reduces appetite by delaying gastric emptying and decreasing intestinal motility. Moreover, preliminary studies have revealed the potential impacts of GLP-1 on various organs such as the heart, fat, muscles, bones, liver, lungs, and kidneys.
While GLP-1 research primarily focuses on treating and preventing diabetes, as well as suppressing appetite, secondary research investigates its potential cardiovascular benefits. Recent studies also highlight the ability of GLP-1 to mitigate neurodegenerative diseases, particularly Alzheimer’s, by slowing down or preventing the accumulation of amyloid beta plaques.
In a phase 3 clinical trial involving overweight or obese adults without diabetes, the efficacy of GLP-1 SG was assessed compared to a placebo, along with lifestyle modifications. A total of 1961 participants received weekly subcutaneous injections of 2.4 mg of GLP-1 SG or placebo over 68 weeks, while both groups received counseling on diet and exercise. The primary outcomes measured were the percentage change in body weight and weight reduction of at least 5%.
At week 68, the mean weight reduction was significantly higher in the GLP-1 SG group compared to the placebo group (14.9% vs. 2.4%; estimated difference of -12.4 percentage points; 95% CI, -13.4 to -11.5). Furthermore, a greater proportion of participants in the GLP-1 SG group achieved a weight loss of at least 5% compared to the placebo group (86.4% vs. 31.5%). Regarding safety, mild to moderate adverse events, mainly gastrointestinal, were reported, leading to treatment discontinuation in 7.0% of the GLP-1 SG group and 3.1% of the placebo group. Serious adverse events, primarily gastrointestinal and hepatobiliary, occurred more frequently in the GLP-1 SG group.
It was concluded overweight or obese adults without diabetes experienced clinically relevant weight loss when treated with weekly injections of GLP-1 SG (2.4 mg) in conjunction with lifestyle modifications.
The primary concern for peptide researchers today is product purity. NordSci guarantees our product purity by performing independent testing of our products and providing those certifications for our customers in our product descriptions.
THIS PRODUCT IS NOT INTENDED TO TREAT, CURE OR DIAGNOSE ANY CONDITION OR DISEASE AND IS NOT FOR HUMAN CONSUMPTION. ALL PRODUCTS OFFERED ARE INTENDED FOR LABORATORY RESEARCH USE ONLY.
